Premium
Cosecretion of amylin and insulin from isolated rat pancreas
Author(s) -
Fehmann H.C.,
Weber V.,
Göke R.,
Göke B.,
Arnold R.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80210-a
Subject(s) - amylin , medicine , insulin , endocrinology , pancreas , chemistry , arginine , radioimmunoassay , endocrine system , glucose homeostasis , stimulation , amino acid , biochemistry , biology , islet , hormone , insulin resistance
Amylin, a 37 amino acid C‐terminal amidated peptide is an integral part of secretory granules of pancreatic β‐cells. Utilizing a specific radioimmunoassay system we demonstrate in the present study a cosecretion of amylin and insulin from the isolated rat pancreas. The secretion pattern of both peptides during glucose or glucose plus arginine stimulation is identical. The molar ratio of amylin amounts to 10% of that of insulin. The biological significance of amylin is still unknown, but a paracrine/endocrine role in glucose homeostasis is speculated.