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Does a 2 ← 5β‐turn structure exist in enkephalins?
Author(s) -
Moret E.,
Gerothanassis I.P.,
Hunston R.N.,
Lauterwein J.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80182-i
Subject(s) - turn (biochemistry) , chemistry , peptide , hydrogen , acetone , enkephalin , crystallography , hydrogen bond , stereochemistry , molecule , biochemistry , organic chemistry , receptor , opioid
The 17 O chemical shifts of the Gly‐2 and Gly‐3 oxygens of a fully protected Leu‐enkephalin were measured to be identical in acetone solution. This allows the conclusion that neither of these peptide oxygens is hydrogen bonded and that no specific 2 ← 5 β‐turn structure exists to an appreciable extent.
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