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Evidence for a single butyrylcholinesterase gene in individuals carrying the C 5 plasma cholinesterase variant (CHE2)
Author(s) -
Masson Patrick,
Chatonnet Arnaud,
Lockridge Oksana
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80167-h
Subject(s) - butyrylcholinesterase , cholinesterase , gene , exon , microbiology and biotechnology , enzyme , biology , biochemistry , chemistry , genetics , acetylcholinesterase , endocrinology , aché
DNA of 3 unrelated individuals carrying the human plasma butyrylcholinesterase C 5 variant (CHE2) was isolated from white blood cells. Southern blot patterns of DNA restriction fragments probed with each of the 4 butyrylcholinesterase exons provided evidence that the production of C 5 is not directed by a second butyrylcholinesterase gene. This finding supports the suggestion that the C 5 variant is a hybrid enzyme resulting from the association of butyrylcholinesterase subunits with a non‐cholinesterase protein.