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Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes
Author(s) -
Sainte-Marie J.,
Vignes M.,
Vidal M.,
Philippot J.R.,
Bienvenüe A.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80141-5
Subject(s) - endocytosis , transferrin receptor , transferrin , receptor mediated endocytosis , benzyl alcohol , chemistry , guinea pig , receptor , lipoprotein , low density lipoprotein , biochemistry , cholesterol , endocrinology , biology , catalysis
We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L 2 C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.