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Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor‐α
Author(s) -
Bravo E.,
Carpinelli G.,
Proietti E.,
Belardelli F.,
Cantafora A.,
Podo F.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80108-u
Subject(s) - phospholipid , diacylglycerol kinase , catabolism , phosphatidylcholine , tumor necrosis factor alpha , leukemia , lipid metabolism , chemistry , biology , endocrinology , biochemistry , medicine , metabolism , enzyme , immunology , protein kinase c , membrane
Lipid analyses were carried out on transplantable murine Friend leukemia cell tumors, 6 h after intratumoral administration of tumor necrosis factor‐α (TNF). The levels of the major phospholipid classes were uniformly decreased to about 70% of control values; free fatty acids were increased to about 170%; diacylglycerol was decreased to about 50% and triacylglycerol, the main lipid component, was not significantly altered. These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous 31 P NMR studies) and histological modifications demonstrated that at early stages of TNF‐induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products.