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Is the pseudo‐dyad in retroviral proteinase monomers structural or evolutionary?
Author(s) -
Rao J.K.Mohana,
Wlodawer Alexander
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80103-p
Subject(s) - rous sarcoma virus , dyad , monomer , biology , pepsin , chemistry , enzyme , virology , virus , computational biology , biochemistry , polymer , psychology , organic chemistry , social psychology
A pseudo‐dyad was found to exist in the monomers of the crystal structures of the proteinases from Rous sarcoma virus and the human immunodeficiency virus. This dyad, also discovered earlier in pepsin‐like aspartic proteinases and considered to be of probable evolutionary origin, has been shown to arise as a result of the topology and the folding of the proteinase monomers and may not therefore have much evolutionary significance.