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Urea cycle disorder in C3H‐H‐2° mice with juvenile steatosis of viscera
Author(s) -
Imamura Yasushi,
Saheki Takeyori,
Arakawa Hiroyuki,
Noda Takashi,
Koizumi Tsutomu,
Nikaido Hiroko,
Hayakawa Jun-ichiro
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80081-s
Subject(s) - juvenile , steatosis , urea cycle , urea , chemistry , medicine , endocrinology , zoology , biology , biochemistry , ecology , amino acid , arginine
We determined the activities of urea cycle enzymes in the liver of C3H‐H‐2 o ‐jsv mice. The activities of all urea cycle enzymes decreased in the latter period of lactation. The activities of carbamylphosphate synthetase and ornithine transcarbamylase in some affected mice were undetectable. On the other hand, the activities of enzymes other than urea cycle enzymes were normal. We consider that the decrease in the urea cycle enzymes is caused by an abnormality in the mechanism of gene expression.