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A biomimetic model for vanadium‐containing bromoperoxidase
Author(s) -
Sakurai Hiromu,
Tsuchiya Koichiro
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80079-x
Subject(s) - chemistry , vanadate , vanadium , oxalate , bromide , malonate , hydrogen peroxide , inorganic chemistry , oxidation state , medicinal chemistry , organic chemistry , metal
A biomimetic model of vanadium‐containing bromoperoxidase (BPO) was proposed. The vanadium‐containing BPO possesses vanadate ion (+5 oxidation state) as a prosteric group and catalyses the formation of a carbon‐bromide bond in the presence of hydrogen peroxide, bromide ion and bromide acceptor. The reaction mechanism is as yet unknown. Several vanadyl (VO 2+ , +4 oxidation state) complexes with oxalate, glutarate, succinate, malonate and acetate ligands showed similar bromination activity to that of BPO. Especially, the vanadyl‐oxalato complex provided the highest BPO‐like activity. Both vanadate ion and vanadyl complexes with nitrogen‐containing ligands such as EDTA, glycine and serine showed essentially no BPO‐like activity. Thus, the vanadyl‐oxalato complex is proposed to be not only a possible chemical model of BPO, but a useful compound to elucidate the reaction mechanism of BPO.