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Kinetoplast DNA‐aggregating proteins from the parasitic protozoan Crithidia fasciculata
Author(s) -
Tittawella Ivor
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80065-q
Subject(s) - crithidia fasciculata , kinetoplast , dna , biology , mitochondrial dna , in vitro , crithidia , genome , mitochondrion , parasite hosting , biochemistry , microbiology and biotechnology , protozoa , genetics , gene , world wide web , computer science
Proteins from C. fasciculata , which preferentially aggregate the parasite's AT‐rich mitochondrial (kinetoplast) DNA in vitro, are reported. The aggregation is non‐topological, non‐covalent, independent of Mg 2+ and ATP, but much improved by spennidine. We discuss how these proteins might modulate the shape and size of the parasite's mitochondrial genome.