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The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
Author(s) -
Yoshida Mitsumori,
Sakai Toshiyuki,
Hosokawa Nobuko,
Marui Nobuyuki,
Matsumoto Katsuhiko,
Fujioka Akihiro,
Nishino Hoyoku,
Aoike Akira
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80053-l
Subject(s) - quercetin , flavonoid , cell cycle , cell growth , cancer , cell cycle progression , cancer cell , cell , chemistry , dna synthesis , cancer research , pharmacology , biology , biochemistry , dna , medicine , antioxidant
Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the IC 50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G 1 to the S phase.