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Liposome‐associated retinoic acid
Author(s) -
Nastruzzi Claudio,
Walde Peter,
Menegatti Enea,
Gambari Roberto
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80030-m
Subject(s) - retinoic acid , liposome , in vitro , chemistry , tretinoin , cell culture , retinoic acid receptor gamma , retinoic acid receptor , biochemistry , cell , retinoic acid receptor beta , retinoic acid inducible orphan g protein coupled receptor , biology , genetics , gene
The activity of liposome‐associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome‐associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10–20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.