Premium
Consensus peptide antibodies reveal a widespread occurrence of Ca 2+ /lipid‐binding proteins of the annexin family
Author(s) -
Gerke Volker
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81668-0
Subject(s) - xenopus , annexin , drosophila melanogaster , antibody , peptide , chemistry , biochemistry , peptide sequence , annexin a2 , annexin a5 , phosphatidylserine , sequence (biology) , biology , genetics , in vitro , gene , phospholipid , membrane
Antibodies generated against synthetic peptides that correspond to highly conserved sequence motifs in the annexins reacted with a variety of annexins from different species. These include Xenopus laevis and Drosophila melanogaster , which contain cross‐reacting polypeptides of apparent M r , 34000 and 30000. As expected for typical annexins, the two Drosophila proteins interact in a Ca 2+ ‐dependent manner with phosphatidylserine liposomes.