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HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III
Author(s) -
Jang K.L.,
Latchman D.S.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81667-9
Subject(s) - transcription (linguistics) , rna polymerase ii , polymerase , rna polymerase i , rna polymerase , microbiology and biotechnology , rna polymerase iii , chemistry , virology , biology , rna , rna dependent rna polymerase , genetics , dna , gene , gene expression , promoter , philosophy , linguistics
The Alu family of repeated sequences is transcribed by both RNA polymerase II and RNA polymerase III. In cells infected with HSV, transcription by polymerase III increases while transcription by polymerase II decreases. By using virus strains carrying mutations in the genes encoding individual regulatory proteins, we have shown that this effect is dependent upon the immediate‐early protein ICP27 and occurs by a process distinct from those which regulate viral gene expression. This is the first example of increased transcription of endogenous cellular sequences by RNA polymerase III during infection with a DNA virus.