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Biosynthesis of small proteoglycans by hepatic lipocytes in primary culture
Author(s) -
Witsch Petra,
Kresse Hans,
Gressner Axel M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81661-8
Subject(s) - biosynthesis , primary culture , chemistry , primary (astronomy) , microbiology and biotechnology , biochemistry , biology , in vitro , gene , physics , astronomy
Chondroitin sulfate/dermatan sulfate proteoglycans were obtained from the secretions of cultured rat hepatic lipocytes. The collagen‐binding small proteoglycan II represented only a minor species (less than 10%), whereas similar amounts of small proteoglycan I and of a novel collagen‐binding proteoglycan with a core protein of 101 kDa were found. These results support the concept of a special role of lipocytes in the pathogenesis of liver fibrosis.