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Poly(ADP‐ribose) polymerase activity is inhibited by 2',5'‐oligoadenylates in mouse L‐cells
Author(s) -
Buonamassa Daniela Tornese,
Malanga Maria,
Coccia Eliana M.,
Romeo Giovanna,
Affabris Elisabetta,
Farina Benedetta,
Suzuki Hisanori
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81641-2
Subject(s) - polymerase , poly adp ribose polymerase , chemistry , microbiology and biotechnology , biochemistry , ribose , enzyme , biology
Down regulation of poly(ADP‐ribose)polymerase (ADPRP) activity was observed in mouse LW‐cells after treatment with 2'‐5'oligoadenylates or with fibroblast interferon and poly(rI).poly(rC). The poly(rI).poly(rC)‐induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2',5'‐oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.