Premium
Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens
Author(s) -
Weiler Rosa,
Cidon Shulamit,
Gershon Michael D.,
Tamir Hadassah,
Hogue-Angeletti Ruth,
Winkler Hans
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81595-9
Subject(s) - chromogranin a , synaptophysin , secretory vesicle , vesicle , secretion , antigen , secretory protein , glycoprotein , biology , enteroendocrine cell , adrenal medulla , microbiology and biotechnology , exocytosis , endocrinology , chemistry , medicine , endocrine system , biochemistry , immunology , immunohistochemistry , hormone , membrane , catecholamine
The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b ‐561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest‐derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.