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Human Na + , K + ‐ATPase genes
Author(s) -
Ushkaryov Yu.A.,
Monastyrskaya G.S.,
Broude N.E.,
Nikiforova N.N.,
Bessarab D.A.,
Orlova M.Yu.,
Petrukhin K.E.,
Modyanov N.N.,
Sverdlov E.D.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81591-1
Subject(s) - pseudogene , gene , complementary dna , microbiology and biotechnology , homology (biology) , protein subunit , biology , transmembrane domain , genetics , coding region , intron , genome
The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na + ,K + ‐ATPase β‐subunit. A partial structure of the βI‐gene was determined, the coding part of which was completely homologous to cDNA of the Na + K + ‐ATPase βI‐subunit from HeLa cells [8]. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (βψ) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the βI‐subunit cDNA from HeLa cells is about 88%.