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Enhancement of colony forming ability in the lung by transfer of the v‐fos oncogene into a ras‐transformed rat 3Y1 cell line
Author(s) -
Nakamatsu Kohji,
Taniguchi Shun'ichiro,
Kimura Genki,
Baba Tsuneo
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81587-x
Subject(s) - oncogene , cell culture , in vivo , cell , cancer research , malignancy , in vitro , lung , cell growth , metastasis , biology , c fos , microbiology and biotechnology , chemistry , cell cycle , cancer , medicine , gene expression , gene , biochemistry , genetics
Transfer of the v‐fos oncogene into a rat 3Y1 cell line transformed by v‐H‐ras, which is tumorigenic but non‐metastatic, enhanced lung metastasis, depending on the amount of fos‐related transcripts. Enhancement of the metastatic potential was associated with increases in tumor growth rate i.m. of inoculated cells but not the rate of in vitro cell growth, irrespective of the addition of tissue (e.g. lung) extract to the regular medium. These results suggest that the v‐fos oncogene increased the malignancy by altering biological factors of the recipient cells responsible for cell growth and/or survival rate in vivo.