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Acidic and basic fibroblast growth factors similarly regulate the rate of biosynthesis of rat astroblast proteins
Author(s) -
Loret Camille,
Laeng Pascal,
Sensenbrenner Monique,
Labourdette Gérard
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81562-5
Subject(s) - fibroblast , polyacrylamide gel electrophoresis , biosynthesis , receptor , fibroblast growth factor , biochemistry , glutamine , cell culture , basic fibroblast growth factor , biology , cell growth , microbiology and biotechnology , chemistry , growth factor , amino acid , gene , enzyme , in vitro , genetics
Quiescent rat astroblasts in culture have been treated for various periods of time with acidic and basic fibroblast growth factors. Both factors elicited similar effects on the cell proliferation and glutamine synthetase activity. The rate of biosynthesis of the proteins analyzed on autoradiograms of polyacrylamide gels after two‐dimensional electrophoresis was also similarly modulated by the two growth factors. These results suggest that the two fibroblast growth factors act through the same membrane receptors on rat astroblasts in culture.