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Conserved residues of tumour necrosis factor and lymphotoxin constitute the framework of the trimeric structure
Author(s) -
Tavernier Jan,
van Ostade Xaveer,
Hauquier Guido,
Prange Thierry,
Lasters Ignace,
de Maeyer Marc,
Lewit-Bentley Anita,
Fourme Roger
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81560-1
Subject(s) - lymphotoxin , lymphotoxin beta receptor , lymphotoxin alpha , tumor necrosis factor alpha , sequence (biology) , necrosis , protein primary structure , peptide sequence , amino acid residue , amino acid , biology , protein structure , conserved sequence , computational biology , chemistry , immunology , biochemistry , genetics , gene
Four distinct areas of primary sequence conservation between known tumour necrosis factor and lymphotoxin polypeptides from various species can be recognized. When these amino acid sequences are highlighted in the three‐dimensional structure, all are found in the same region, constituting the framework of the trimeric structure.