Premium
Prothymosin α is an evolutionary conserved protein covalently linked to a small RNA
Author(s) -
Makarova Tatyana,
Grebenshikov Nickolay,
Egorov Cesiy,
Vartapetian Andrey,
Bogdanov Alexey
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81544-3
Subject(s) - rna , biochemistry , biology , conserved sequence , yeast , cytoplasm , microbiology and biotechnology , peptide sequence , genetics , gene
A 13 kDa protein, covalently linked to a small RNA from the cytoplasm of mouse cells, was studied. Sequence analysis of its tryptic peptides revealed that the RNA‐linked protein is identical to prothymosin α. Very similar RNA‐protein complexes were identified in human, bovine and yeast cells. Tryptic peptide maps of 125 I‐labelled RNA‐linked proteins of diverse origin demonstrated their marked similarity, thus indicating high evolutionary conservation of prothymosin α from yeast to man.