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Thyroid hormone stimulates expression of 6‐phosphofructo‐2‐kinase in rat liver
Author(s) -
Wall Stephen R.,
van den Hove Marie-France,
Crepin Karine M.,
Hue Louis,
Rousseau Guy G.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81536-4
Subject(s) - thyroid , hormone , endocrinology , medicine , biology
The activity of liver 6‐phosphofructo‐2‐kinase (PFK‐2), the enzyme that catalyses the synthesis of fructose 2,6‐bisphosphate, was markedly decreased in hypothyroid rats and partially restored after 3 days of treatment with triiodothyronine. The changes in PFK‐2 activity were accompanied by parallel changes in enzyme content measured by immunotitration and in PFK‐2 mRNA determined by dot blot and Northern blot hybridization with cDNA probes. It is concluded that thyroid hormone stimulates liver PFK‐2 gene expression by a pre‐translational mechanism.