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Secretion of islet amyloid polypeptide in response to glucose
Author(s) -
Kanatsuka A.,
Makino H.,
Ohsawa H.,
Tokuyama Y.,
Yamaguchi T.,
Yoshida S.,
Adachi M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81527-3
Subject(s) - islet , amyloid (mycology) , secretion , medicine , endocrinology , radioimmunoassay , extracellular , pancreatic islets , glucose homeostasis , chemistry , homeostasis , blood sugar regulation , regulator , diabetes mellitus , biochemistry , biology , insulin resistance , inorganic chemistry , gene
The content of isolet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse‐phase high‐performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.