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Effect of insulin on glucose transporter distribution in white fat cells from hypophysectomized rats
Author(s) -
Keller Susanne,
Zapf Juergen
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81525-x
Subject(s) - medicine , endocrinology , cytochalasin b , glucose transporter , insulin , basal (medicine) , chemistry , adipose tissue , microsome , hypophysectomy , biology , biochemistry , in vitro , hormone
Glucose transport in white fat cells from hypophysectomized rats is increased and unresponsive to insulin. The goal of this study was to explain this observation. The number of glucose transporters, as determined by D‐glucose‐inhibitible cytochalasin B binding, in the plasma membranes from fat cells of hypophysectomized rats is: (1) elevated, (2) not increased by insulin, and (3) the same as in plasma membranes from insulin‐stimulated fat cells of control rats. In microsomal membranes from fat cells of hypophysectomized rats the number of glucose transporters is: (1) smaller than in basal and insulin‐stimulated fat cells from control rats, and (2) not changed by insulin.