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Surfactant enhancement of polyethyleneglycol‐induced cell fusion
Author(s) -
Prado Adelina,
Partearroyo M.Aránzazu,
Mencía Mario,
Goñi Félix M.,
Barberá-Guillem Emilio
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81515-7
Subject(s) - pulmonary surfactant , chemistry , biophysics , cell fusion , fusion , chemical engineering , cell , chromatography , biochemistry , biology , engineering , linguistics , philosophy
B 16 mouse melanoma cells in monolayers may be satisfactorily fused with 50% PEG 1500. However, pre‐treatment with detergents in solution at low concentrations significantly increases PEG fusion, up to 8‐fold in some instances, without impairing cell viability. The practical and mechanistical implications of this finding are discussed.