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Expression of retinoic acid receptor genes in keratinizing front of skin
Author(s) -
Noji Sumihare,
Yamaai Tomoichiro,
Koyama Eiki,
Nohno Tsutomu,
Fujimoto Wataru,
Arata Jiro,
Taniguchi Shigehiko
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81501-7
Subject(s) - retinoic acid , keratin , epidermis (zoology) , retinoic acid receptor , retinoic acid receptor beta , in situ hybridization , retinoic acid receptor gamma , retinoic acid receptor alpha , biology , microbiology and biotechnology , retinoic acid inducible orphan g protein coupled receptor , complementary dna , keratin 6a , gene , retinoid x receptor gamma , gene expression , cell , biochemistry , intermediate filament , cytoskeleton , anatomy , genetics
We found, by an in situ hybridization method with riboprobes synthesized from human cDNA of the retinoic acid receptor (RAR), that the RAR genes (predominantly γ‐subtype) are intensively expressed in the epidermis of normal and psoriasic human skins, and also in keratinizing fronts of 4‐day‐old mouse skins, nail matrices and hair follicles. Thus, target cells of retinoic acid in the skins are concluded to be keratinocytes, which is quite consistent with the fact that retinoic acid regulates keratinization of epidermis in vivo and also modulates expression of the keratin gene in vitro.