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Potent selective inhibitors of protein kinase C
Author(s) -
Davis Peter D.,
Hill Christopher H.,
Keech Elizabeth,
Lawton Geoffrey,
Nixon John S.,
Sedgwick Anthony D.,
Wadsworth Julie,
Westmacott Donald,
Wilkinson Sandra E.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81494-2
Subject(s) - staurosporine , protein kinase c , chemistry , protein kinase a , kinase , biochemistry , enzyme
A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).