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Chronic long‐term electrostimulation creates a unique metabolic enzyme profile in rabbit fast‐twitch muscle
Author(s) -
Hood David A.,
Pette Dirk
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81393-6
Subject(s) - soleus muscle , stimulation , glycolysis , citrate synthase , medicine , isozyme , enzyme , endocrinology , skeletal muscle , tibialis anterior muscle , tetanic stimulation , chemistry , biology , biochemistry , inhibitory postsynaptic potential , excitatory postsynaptic potential
Long‐term low‐frequency stimulation (up to 120 days) of rabbit fast‐twitch tibialis anterior muscle led, in a first‐order‐like time course, to changes in enzyme activities of energy metabolism which became stable with ongoing stimulation after 50 days. The glycolytic enzymes decreased to 30–40% of their normal values, but remained 2–3‐fold higher than in heart or soleus muscle. The LDH isozyme pattern ultimately resembled that of the slow‐twitch soleus muscle. Citrate synthase activity increased 3.7‐fold which brought this enzyme to a value 45% above that of heart. These results indicate that chronic stimulation does not simply convert the fast‐twitch muscle into a soleus‐like slow‐twitch muscle, but creates a tissue of unique metabolic properties.