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Mitochondrial porin regulates the sensitivity of anion carriers to inhibitors
Author(s) -
Pronevich Ludmila A.,
Mirzabekov Tajib A.,
Rozhdestvenskaya Zinaida E.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81363-8
Subject(s) - porin , voltage dependent anion channel , mitochondrion , antiporter , biochemistry , bacterial outer membrane , activator (genetics) , chemistry , respiratory chain , respiration , biophysics , membrane , biology , anatomy , receptor , escherichia coli , gene
In mitoplasts, respiratory stimulation by ADP, palmitate, DNP and CCCP and sensitivity of respiration to carboxyatractylate are considerably less pronounced than in mitochondria. Addition of porin‐containing preparations (purified outer membranes or solubilized mitochondrial porin) to mitoplasts results in partial restoration of the oxygen consumption and sensitivity to carboxyatractylate (CAT). The uncoupling effect of FCCP in mitoplasts is CAT‐resistant and does not depend on added porin. It is suggested that mitochondrial porin may be a natural activator of ADP/ATP antiporter and succinate carrier in mitochondria.