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Bradykinin stimulates tumor necrosis factor and interleukin‐1 release from macrophages
Author(s) -
Tiffany Carol W.,
Burch Ronald M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81331-6
Subject(s) - bradykinin , tumor necrosis factor alpha , cytokine , bradykinin receptor , kinin , inflammation , interleukin , chemistry , receptor , proinflammatory cytokine , endocrinology , immunology , medicine , pharmacology
Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many inflammatory diseases. The potential ability of bradykinin to stimulate release of tumor necrosis factor and interleukin‐1 from macrophages was examined. Bradykinin stimulated release of both cytokines from P388‐D1 and RAW264.7 murine macrophages. Studies with selective agonists and antagonists suggest that cytokine release is mediated by a B 1 kinin receptor.