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The complete islet amyloid polypeptide precursor is encoded by two exons
Author(s) -
Mosselman S.,
Höppener J.W.M.,
Lips C.J.M.,
Jansz H.S.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81260-8
Subject(s) - islet , exon , amyloid (mycology) , chemistry , biochemistry , microbiology and biotechnology , genetics , biology , endocrinology , gene , insulin , inorganic chemistry
Islet amyloid polypeptide (IAPP) is the 37‐amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227–232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89‐amino acid pre‐pro‐IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino‐terminus of the precursor suggests that IAPP is a secreted protein.