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Inhibition of reverse transcription in rat liver intracisternal A‐particles by thymidine derivatives
Author(s) -
Pyrinova Galina B.,
Kuzminova Elena A.,
Salganik Rudolf I.,
Krayevsky Alexander A.,
Kukhanova Marina M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81240-2
Subject(s) - thymidine , reverse transcriptase , transcription (linguistics) , dna , microbiology and biotechnology , chemistry , dna polymerase , dna synthesis , biology , biochemistry , rna , gene , linguistics , philosophy
The thymidine derivatives araAzT, dTTP(3′N 3 ), TTP(3′NH 2 ), and araTTP(3′N 3 ), were studied as inhibitors of the reverse transcription taking place within endogenous retroviral A‐type particles, where retroviral RNAs served as templates and primers. dTTP(3′N 3 ) was shown to be the most efficient inhibitor of retroviral particle reverse transcription. Termination of DNA chain elongation is the basic mechanism of the inhibitory action of dTTP(3′N 3 ). The compound has a very low inhibitory effect on mammalian DNA‐dependent DNA polymerases α, β and γ.