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Immunological evidence that insulin activates protein kinase C in BC3H‐1 myocytes
Author(s) -
Acevedo-Duncan Mildred,
Cooper Denise R.,
Standaert Mary L.,
Farese Robert V.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81186-x
Subject(s) - myocyte , microbiology and biotechnology , chemistry , insulin , medicine , endocrinology , biology
Effects of insulin on immunoreactive protein kinase C were examined in BC3H‐1 myocytes. Insulin provoked rapid dose‐dependent decreases in cytosolic enzyme, and transient increases and subsequent decreases in membrane‐associated enzyme. Phorbol esters provoked similar changes. Our findings suggest that insulin provokes the translocative activation of protein kinase C.