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The angiotensinogen gene is located on mouse chromosome 8
Author(s) -
Clouston W.M.,
Fournier R.E.K.,
Richards R.I.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81136-6
Subject(s) - centimorgan , biology , gene , microbiology and biotechnology , chromosome , inbred strain , chromosome 4 , genetics , gene expression , chromosome 17 (human) , recombinant dna , salivary gland , gene mapping , biochemistry
We have recently identified a cis ‐acting genetic lesion affecting angiotensinogen gene expression in testis and salivary gland. Accordingly, the angiotensinogen gene was assigned to mouse chromosome 8 by screening a series of hybrid cell lines for retention of mouse angiotensinogen sequences by genomic Southern analysis. In AKXD recombinant inbred mice, the angiotensinogen gene is 2.4 ± 1.8 centiMorgan from Rn7S‐8 , a 7S RNA gene located on chromosome 8 (Taylor, B.A., personal communication). However, the segregation of salivary and testicular angiotensinogen expression phenotypes into inbred mouse strains was not concordant with the known chromosome 8 proviruses Emv‐2 , Mtv‐21 , Xmv‐12 or Xmv‐26 .