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Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor
Author(s) -
Onai Takeshi,
FitzGerald Michael G.,
Arakawa Shoji,
Gocayne Jeannine D.,
Urquhart Deborah A.,
Hall Linda M.,
Fraser Claire M.,
McCombie W.Richard,
Venter J.Craig
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81095-6
Subject(s) - muscarinic acetylcholine receptor , cloning (programming) , acetylcholine receptor , genetics , biology , sequence analysis , drosophila (subgenus) , muscarinic acetylcholine receptor m3 , sequence (biology) , receptor , gene , computer science , programming language
Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis. The Drosophila muscarinic receptor contains 788 amino acids with a calculated M r of 84 807 and displays greater than 60% homology with mammalian muscarinic receptors. The muscarinic receptor maps to the tip of the right arm of the second chromosome of the Drosophila genome.