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Formation of endothelin by cultured airway epithelial cells
Author(s) -
Black P.N.,
Ghatei M.A.,
Takahashi K.,
Bretherton-Watt D.,
Krausz T.,
Dollery C.T.,
Bloom S.R.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81075-0
Subject(s) - endothelin receptor , gel permeation chromatography , chemistry , endothelin 1 , elution , chromatography , microbiology and biotechnology , biology , biochemistry , receptor , organic chemistry , polymer
Immunoreactivity to endothelin was detected in conditioned culture medium from both canine and porcine tracheal epithelial cells. Gel permeation chromatography and fast protein liquid chromatography were used to confirm the identity of the endothelin. The two peaks demonstrated on fast protein liquid chromatography co‐eluted with endothelin 1 and endothelin 3 respectively.