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Identification of the ferroxidase centre in ferritin
Author(s) -
Lawson David M.,
Treffry Amyra,
Artymiuk Peter J.,
Harrison Pauline M.,
Yewdall Stephen J.,
Luzzago Alessandra,
Cesareni Gianne,
Levi Sonia,
Arosio Paolo
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81040-3
Subject(s) - ceruloplasmin , ferritin , identification (biology) , chemistry , biochemistry , computational biology , biology , botany
Ferroxidase activity in human H‐chain ferritin has been studied with the aid of site‐directed mutagenesis. A site discovered by X‐ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H‐chains and is located within the four‐helix bundle of the chain fold.