Premium
Identity of G D1C , G T1a and G Q1b synthase in Golgi vesicles from rat liver
Author(s) -
Iber Heinrich,
Sandhoff Konrad
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81022-1
Subject(s) - ganglioside , sialyltransferase , golgi apparatus , vesicle , enzyme , biochemistry , chemistry , biosynthesis , golgi membrane , glycosyltransferase , biology , membrane , cell
Competition experiments using G M1b , G D1a and G T1b as substrates, and as mutual inhibitors for ganglioside sialyltransferase activity in preparations of Golgi vesicles derived form rat liver, suggested that sialyl transfer to these three respective compounds, leading to gangliosides G D1C , G T1a and G Q1b , respectively, is catalyzed by one enzyme. These results are incorporated into a model for ganglioside biosynthesis and its regulation.