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Heterogeneous activation of protein kinase C during rat liver regeneration induced by carbon tetrachloride administration
Author(s) -
Sasaki Yutaka,
Hayashi Norio,
Ito Toshifumi,
Fusamoto Hideyuki,
Sato Nobuhiro,
Kamada Takenobu
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)81009-9
Subject(s) - carbon tetrachloride , subspecies , protein kinase a , liver regeneration , regeneration (biology) , protein kinase c , kinase , alpha (finance) , chemistry , microbiology and biotechnology , biology , biochemistry , medicine , paleontology , construct validity , nursing , organic chemistry , patient satisfaction
During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase C α subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase C α subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing the protein kinase C α subspecies was roughly coincident with that of hepatocytes exhibiting DNA synthesis. These results suggest that protein kinase C may play a crucial role in liver regeneration.