Premium
Gene structure of rat cathepsin H
Author(s) -
Ishidoh Kazumi,
Kominami Eiki,
Katunuma Nobuhiko,
Suzuki Koichi
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80939-1
Subject(s) - exon , gene , cysteine , intron , cathepsin l , microbiology and biotechnology , cathepsin , chemistry , biology , cathepsin e , genetics , biochemistry , cathepsin o , enzyme
The gene structure of rat cathepsin H was determined. It comprises at least 12 exons of various lengths (32–433 bp) spanning in total more than 17.5 kbp. The gene structure does not correspond well to the functional unit of the proteinase. The region around the active site Cys residue, the most conserved region among cysteine proteinases, is split by an intron. This is a common characteristic among the gene structures of cysteine proteinases.