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Transcription of the dystrophin gene in Duchenne muscular dystrophy muscle
Author(s) -
Muntoni Francesco,
Strong Peter N.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80896-8
Subject(s) - dystrophin , duchenne muscular dystrophy , muscular dystrophy , gene , polymerase chain reaction , itga7 , muscle biopsy , biology , transcription (linguistics) , microbiology and biotechnology , genetics , biopsy , medicine , pathology , linguistics , philosophy
Dystrophin is the recently discovered defective gene product in Duchenne and Becker muscular dystrophy (DMD and BMD). Dystrophin transcripts have been amplified and identified in diagnostic needle muscle biopsy samples using the polymerase chain reaction (PCR) procedure. Using 5′‐ and 3′‐primers, dystrophin transcripts can be detected in both DMD and BMD muscle biopsies, on either side of defined deletions within the dystrophin gene.