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Correlation between the OH bond dissociation energies of ellipticine hydroxylated derivatives and their cytotoxic properties
Author(s) -
Rousseau-Richard C.,
Auclair C.,
Richard C.,
Martin R.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80889-0
Subject(s) - chemistry , cytotoxic t cell , dissociation (chemistry) , bond dissociation energy , stereochemistry , computational chemistry , organic chemistry , biochemistry , in vitro
The O−H bond dissociation energies (BDEs) of ellipticine‐derived hydroxylated compounds have been evaluated by a kinetic method and are shown to correlate with the cytotoxic activity of these derivatives.