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NMR studies of lantibiotics Assignment of the 1 H‐NMR spectrum of nisin and identification of interresidual contacts
Author(s) -
Slijper M.,
Hilbers C.W.,
Konings R.N.H.,
van de Ven F.J.M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80883-x
Subject(s) - nisin , lantibiotics , chemistry , residue (chemistry) , carbon 13 nmr , molecule , nuclear magnetic resonance spectroscopy , proton nmr , antimicrobial , stereochemistry , biochemistry , organic chemistry
Nisin is a 34 residue long antimicrobial polypeptide, which contains unusual α,β‐unsaturated amino acids as well as lanthionines. By making use of 2D‐NMR methods, the complete 1 H‐NMR spectrum of the polypeptide could be assigned. The NMR data indicate that the molecule adopts a well‐defined three‐dimensional structure.