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Towards the development of antimicrobial drugs acting by inhibition of pathogen attachment to host cells: A need for polyvalency
Author(s) -
Matrosovich Mikhail N.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80879-8
Subject(s) - antimicrobial , pathogen , microbiology and biotechnology , chemistry , host (biology) , human pathogen , biology , biochemistry , genetics , gene
The development of inhibitors of microbial attachment to target cells has been proposed recently as a possible novel approach to antimicrobial chemoprophylaxis and treatment. In this paper an attempt is made to contend that such artificial inhibitors must be polyvalent, i.e. capable of binding to the pathogen or its target by multiple bonds.