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Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes
Author(s) -
Kerler Franz,
Ziegler Irmgard,
Schwarzkopf Bruno,
Bacher Adelbert
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80809-9
Subject(s) - tetrahydrobiopterin , gtp cyclohydrolase i , stimulation , lectin , gtp' , biopterin , chemistry , biochemistry , biology , medicine , enzyme , endocrinology , cofactor
Lectin stimulation of human T lymphocytes causes a 7‐fold increase in the specific activities of GTP‐cyclohydrolase and a 4‐fold increase in the specific activities of sepiapterin reductase. GTP‐cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities continue to increase during the 72 h period measured. The specific activities of 6‐pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP‐cyclohydrolase and sepiapterin reductase.