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Charybdotoxin blocks dendrotoxin‐sensitive voltage‐activated K + channels
Author(s) -
Schweitz Hugues,
Stansfeld Catherine E.,
Bidard Jean-Noël,
Fagni Laurent,
Maes Pierrette,
Lazdunski Michel
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80788-4
Subject(s) - charybdotoxin , peptide , chemistry , neurotoxin , biochemistry , membrane potential
Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca 2+ ‐activated K + channels also blocks a class of voltage‐sensitive K + channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such as dendrotoxin and MCD peptide. Charybdotoxin also inhibits 125 ‐dendrotoxin and 125 I‐MCD peptide binding to their receptors. All these effects are observed with an IC 50 of about 30 nM.