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Effect of persistent measles virus infection on protein kinase C activity and c‐fos protooncogene expression in neuroblastoma cells
Author(s) -
Wolfson M.,
Katorza A.,
Segal S.,
Rager-Zisman B.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80757-4
Subject(s) - measles virus , protein kinase c , biology , virus , microbiology and biotechnology , cell culture , gene expression , signal transduction , virology , protein kinase a , messenger rna , gene , neuroblastoma , kinase , measles , biochemistry , vaccination , genetics
The effect of persistent measles virus infection on c‐fos protooncogene and protein kinase C (PKC‐I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c‐fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC‐I‐specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.