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Fatty acid acylated antibodies against virus suppress its reproduction in cells
Author(s) -
Kabanov A.V.,
Ovcharenko A.V.,
Melik-Hubarov N.S.,
Bannikov A.I.,
Alakhov V.Yu.,
Kiselev V.I.,
Sveshnikov P.G.,
Kiselev O.I.,
Levashov A.V.,
Severin E.S.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80729-x
Subject(s) - antibody , virus , reproduction , biology , virology , intracellular , immunology , microbiology and biotechnology , ecology
A method for suppression of virus reproduction in cells using fatty acylated antiviral antibodies, which in contrast to non‐modified antibodies are capable of intracellular penetration, has been suggested. The addition of stearoylated antiviral antibodies to influenza A/Chili virus‐infected cells causes a 100‐fold suppression of virus reproduction. Non‐modified antibodies do not produce any effect on virus reproduction.