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Isolation and structure of corazonin, a cardioactive peptide from the American cockroach
Author(s) -
Veenstra Jan A.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80727-6
Subject(s) - periplaneta , dictyoptera , cockroach , american cockroach , peptide , blattidae , neuropeptide , medicine , endocrinology , biology , chemistry , biochemistry , receptor , ecology
Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, Periplaneta americana , and its structure determined to be Glp‐Thr‐Phe‐Gln‐Tyr‐Ser‐Arg‐Gly‐Trp‐Thr‐Asn‐amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.