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The role of ubiquinones in the regulation of lipid metabolism in rat thymocytes
Author(s) -
Novoselova E.G.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80661-1
Subject(s) - lipid metabolism , chemistry , metabolism , biochemistry , microbiology and biotechnology , biology
The effect of ubiquinones Q‐1, Q‐2, Q‐8 and Q‐9 on lipid metabolism in rat thymocytes in vitro was studied. The cells were incubated in a medium containing ubiquinones within the concentration range from 1 to 1OOμM. A 2‐fold decreased cholesterol synthesis was observed in thymocytes incubated with ubiquinone Q‐9 at a concentration of exogenous ubiquinone of no less than 40 μM. Incubation of thymocytes with ubiquinones UQ‐1 and UQ‐2 that are characteristic of rats (40 μM and 100 μM) resulted in a decrease of cholesterol synthesis. Ubiquinone‐8 had a tendency to inhibit the cholesterogenesis in rat thymocytes.